What size filter is required for administering Amphotericin B?

The requirement for a 1 micron filter for administering Amphotericin B is based on the need to prevent the infusion of any potential particulate matter or fungal contaminants that could arise from the formulation. Amphotericin B is known to aggregate, and using a filter of this size helps to trap any particles or aggregates that could cause adverse reactions or complications during administration.

Filters that are smaller than 1 micron might be too restrictive, potentially causing issues with flow rates and leading to incomplete administration of the medication. Filters larger than 1 micron are not adequate to effectively trap the particulates associated with Amphotericin B, which could lead to potential complications for the patient. Thus, the 1 micron filter strikes an appropriate balance, ensuring safety while allowing for proper drug delivery.