What precaution should be taken when administering bleomycin sulfate?

When administering bleomycin sulfate, it is crucial to give a test dose before the full administration. This precaution is necessary because bleomycin can cause severe hypersensitivity reactions and pulmonary toxicity in some patients. The test dose helps to identify any potential allergic reactions or intolerances the patient may have to the medication.

By administering a small amount initially, healthcare providers can monitor the patient for any adverse effects that may occur. If a reaction is observed, further administration of bleomycin can be avoided, thus ensuring patient safety. The importance of this precaution cannot be understated given the medication's potential severe complications.

Other options do not adequately emphasize the necessity of assessing patient response prior to full drug administration. Without a test dose, there is a higher risk of severe allergic reactions, making the recommended practice of administering a test dose imperative.