What potential side effect should be monitored when administering Primaxin?

Monitoring for hypernatremia when administering Primaxin (imipenem/cilastatin) is particularly important due to the drug's potential impact on fluid and electrolyte balance. Primaxin can lead to alterations in sodium levels due to its effects on kidney function and fluid regulation in the body, especially in patients with pre-existing conditions that may predispose them to sodium imbalances.

Additionally, imipenem is a broad-spectrum antibiotic that can affect various systems in the body, and disturbances in sodium levels may arise as a side effect of the medication. Keeping track of serum sodium levels is crucial, particularly in patients who might be receiving other medications or treatments that also affect fluid and electrolyte levels. It’s important for healthcare professionals to be vigilant in monitoring for symptoms related to hypernatremia, which can include neurological changes, confusion, and lethargy.

This focus on hypernatremia is essential in ensuring patient safety and effective management during antibiotic therapy.