What is a primary concern when giving Mannitol intravenously?

When administering Mannitol intravenously, a primary concern revolves around its potential to be vein irritating. Mannitol is a hyperosmotic agent, and as such, it can cause irritation to the endothelial lining of the veins. This can lead to phlebitis, which is the inflammation of a vein, or other complications such as thrombosis if the infusion is not managed correctly. The ability of Mannitol to draw water into the vascular space generates high osmotic pressure, which can exacerbate discomfort at the injection site and necessitate careful monitoring of administration techniques to prevent tissue damage and maintain patient comfort.

While the other options highlight important considerations, such as the risk of infection associated with any intravenous therapy, the need for hydration for effective action of Mannitol, and the requirement for constant monitoring due to the effects of mannitol on fluid and electrolyte balance, these are secondary to the immediate concern of vein irritation. Ensuring that intravenous Mannitol is delivered through a proper line, ideally with a large-bore catheter, can minimize the risk of irritation and subsequent complications.